The Comparative Study of Sodium Valproate and Topiramate as Prophylactic Therapy for Migraine in Imam Hospitals of Tabriz and Urmia, Northwestern Iran

Abstract

Migraine, generally unilateral and throbbing, is a periodic headache with a genetically background. It begins from childhood, adolescence or early in middle age and is more common among the women. According to conventional terminology two main clinical syndromes associated with migraine: migraine with and without aura. Although extensive studies and hypotheses have been done, the definite pathology of migraine is not
clear. However, two main neurogenic and vasogenic hypotheses are generally accepted. Although the criteria proposed by ICHD-2 are suitable for research purposes, almost physicians diagnose the migraine based on its general manifestations. The 80% of the untreated patients will suffer moderate to severe pains and only in 20% of the cases they experience a mild pain. In this study, we tried to evaluate the general and detailed effects
of sodium valproate and topiramate as a prophylactic therapy for migraine episodes.